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Expression of integrin β-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics.

Samrat Roy ChoudhuryStephanie D ByrumDuah AlkamCody AshbyFenghuang ZhanAlan J TackettFrits Van Rhee
Published in: Clinical epigenetics (2023)
Our findings suggest an epigenetic regulation of oncogenic overexpression of ITGB7 in MM cells, which could be critical in MM progression and an attractive therapeutic target.
Keyphrases
  • multiple myeloma
  • induced apoptosis
  • poor prognosis
  • transcription factor
  • cell cycle arrest
  • cell proliferation
  • endoplasmic reticulum stress
  • oxidative stress
  • signaling pathway
  • cell death
  • binding protein