Early Initiation of Sub-Anesthetic Ketamine Infusion in Adults with Vaso-Occlusive Crises Is Associated with Greater Reduction in Sickle Cell Pain Intensity: A Single Center's Experience.

Martha O KenneyBenjamin BecerraArvind MallikarjunanNirmish ShahWally R Smith

Published in: Pain medicine (Malden, Mass.) (2022)

In a nonrandomized study of sickle cell patients with VOCs, early sub-anesthetic ketamine infusion led to greater reduction in subjective pain intensity than late initiation of the infusion. Randomized studies should further explore whether early vs late ketamine infusion improves management of acute SCD pain.

Keyphrases

pain management
chronic pain
low dose
neuropathic pain
high intensity
sickle cell disease
open label
randomized controlled trial
clinical trial
respiratory failure
sleep quality
drug induced
acute respiratory distress syndrome
case control
aortic dissection