Prognostic significance of tumor-infiltrating lymphocytes may differ depending on Ki67 expression levels in estrogen receptor-positive/HER2-negative operated breast cancers.
Yukie FujimotoTakahiro WatanabeAkira I HidaTomoko HiguchiYoshimasa MiyagawaHiromi OzawaAyako BunReiko FukuiAtsushi SataMichiko ImamuraSeiichi HirotaYasuo MiyoshiPublished in: Breast cancer (Tokyo, Japan) (2019)
In Ki67-high breast cancers, high TILs were associated with favorable DFS, irrespective of subtype, but increasing TIL levels correlated with worse DFS in the Ki67-low group with the ER + /HER2 - subtype. These results highlight variation in TIL prognostic significance between Ki67-high and -low breast cancers, particularly for the ER + /HER2 - subtype.