Neuronal apoE4 induces early hyperexcitability in select populations of hippocampal neurons by altering Nell2 expression.
Sung-Soo JangDennis R TabuenaBrian GroneOscar YipJessica BlumenfeldNicole KoutsodendrisLeonardo DingQin XuSeo Yeon YoonYadong HuangMisha ZilberterPublished in: bioRxiv : the preprint server for biology (2023)
ApoE4 causes hyperexcitability of select hippocampal neurons in young apoE4 mice.ApoE4 causes dentate hyperexcitability and inhibitory deficit in aged apoE4 mice.snRNA-seq reveals apoE genotype-, cell type-, and age-dependent transcriptomic changes.Nell2 overexpression identified as a cause of apoE4-induced neuronal hyperexcitability.
Keyphrases
- cognitive decline
- high fat diet
- mild cognitive impairment
- cerebral ischemia
- spinal cord
- single cell
- adipose tissue
- poor prognosis
- gene expression
- cell proliferation
- type diabetes
- dna methylation
- transcription factor
- high fat diet induced
- insulin resistance
- oxidative stress
- blood brain barrier
- binding protein
- middle aged
- drug induced
- subarachnoid hemorrhage