Effect of β-hydroxy-β-methylbutyrate on miRNA expression in differentiating equine satellite cells exposed to hydrogen peroxide.
Karolina A ChodkowskaAnna CiecierskaKinga MajchrzakPiotr OstaszewskiTomasz SadkowskiPublished in: Genes & nutrition (2018)
Our results suggest that ESC pre-incubated with HMB and exposed to H2O2 could affect expression on miRNA levels responsible for skeletal muscle development, cell proliferation and differentiation, and activation of tissue repair after injury. Enrichment analyses for targeted genes revealed that a large group of genes was associated with the regulation of signaling pathways crucial for muscle tissue development, protein metabolism, muscle injury, and regeneration, as well as with oxidative stress response.
Keyphrases
- skeletal muscle
- hydrogen peroxide
- poor prognosis
- cell proliferation
- induced apoptosis
- binding protein
- genome wide
- signaling pathway
- stem cells
- nitric oxide
- insulin resistance
- pi k akt
- cell cycle arrest
- genome wide identification
- type diabetes
- cancer therapy
- cell cycle
- single cell
- gene expression
- metabolic syndrome
- magnetic resonance imaging
- amino acid
- drug delivery
- small molecule
- wound healing