The expression of genes in top obesity-associated loci is enriched in insula and substantia nigra brain regions involved in addiction and reward.
Fatou K NdiayeMarlène HuyvaertAna OrtalliMickaël CanouilCécile LecoeurMarie VerbanckStéphane LobbensAmna KhamisLorella MarselliPiero MarchettiJulie Kerr-ConteFrançois PattouMichel MarreRonan RousselBeverley BalkauPhilippe FroguelAmélie BonnefondPublished in: International journal of obesity (2005) (2019)
Our data suggest for the first time that the susceptibility genes for common obesity may have an effect on eating addiction and reward behaviors through their high expression in substantia nigra and insula, i.e., a different pattern from monogenic obesity genes that act in the hypothalamus and cause hyperphagia. Further epidemiological studies with relevant food behavior phenotypes are necessary to confirm these findings.
Keyphrases
- weight loss
- genome wide
- insulin resistance
- metabolic syndrome
- high fat diet induced
- poor prognosis
- type diabetes
- weight gain
- functional connectivity
- bioinformatics analysis
- resting state
- genome wide identification
- dna methylation
- physical activity
- binding protein
- genome wide analysis
- adipose tissue
- body mass index
- skeletal muscle
- gene expression
- long non coding rna
- risk assessment
- genome wide association study
- machine learning
- human health