Effects of ketamine on circadian rhythm and synaptic homeostasis in patients with treatment-resistant depression: A protocol for mechanistic studies of its rapid and sustained antidepressant actions in humans.
Chuanjun ZhuoHongjun TianGongying LiMin ChenDeguo JiangXiaodong LinYong XuWenqiang WangPublished in: Brain and behavior (2019)
This clinical study protocol is the first, to our knowledge, to describe the prospective testing of the hypothesis that daytime and nighttime administrations of ketamine would have different antidepressant effects. The brain imaging, sleep, and genetic findings from patients with treatment-resistant depression are expected to shed new light on the mechanisms of ketamine and its interaction with target sites in the brain, which can be used for objective evaluation of the efficacy of ketamine.
Keyphrases
- sleep quality
- pain management
- randomized controlled trial
- major depressive disorder
- study protocol
- depressive symptoms
- resting state
- white matter
- healthcare
- high resolution
- clinical trial
- functional connectivity
- obstructive sleep apnea
- physical activity
- genome wide
- atrial fibrillation
- heart rate
- cerebral ischemia
- gene expression
- blood pressure
- mass spectrometry
- copy number
- dna methylation
- prefrontal cortex
- bipolar disorder
- double blind