LAG-3 expression in the inflammatory microenvironment of glioma.

Maximilian J MairBarbara KieselKatharina FeldmannGeorg WidhalmKarin DieckmannAdelheid WöhrerLeonhard MüllauerMatthias PreusserAnna Sophie Berghoff

Published in: Journal of neuro-oncology (2021)

LAG-3 is only rarely expressed on TILs in IDH-wildtype glioma and associated with active inflammatory milieu as defined by higher TIL density. Immune microenvironment diversity should be considered in the design of future immunotherapy trials in glioma.

Keyphrases

stem cells
oxidative stress
poor prognosis
low grade
current status
high grade