Platelet-Rich Plasma Versus Alternative Injections for Osteoarthritis of the Knee: A Systematic Review and Statistical Fragility Index-Based Meta-analysis of Randomized Controlled Trials.
Jacob F OedingNathan H VaradyForrest W FearingtonAyoosh PareekSabrina M StricklandBenedict U NwachukwuChristopher L CampAaron John KrychPublished in: The American journal of sports medicine (2024)
Conclusions drawn from individual RCTs evaluating PRP for knee OA demonstrated slight robustness. On meta-analysis, PRP demonstrated a significant advantage over hyaluronic acid as well as improved symptom relief, lower rates of reintervention, and more frequent achievement of the MCID for pain improvement when compared with alternative nonoperative treatment options. Statistically significant pooled treatment effects evaluating PRP for knee OA are more robust than approximately half of all comparable meta-analyses in medicine and health care. Future RCTs and meta-analyses should consider reporting FIs and fragility quotients to facilitate interpretation of results in their proper context.
Keyphrases
- platelet rich plasma
- meta analyses
- knee osteoarthritis
- systematic review
- hyaluronic acid
- total knee arthroplasty
- randomized controlled trial
- healthcare
- anterior cruciate ligament
- chronic pain
- anterior cruciate ligament reconstruction
- rheumatoid arthritis
- neuropathic pain
- pain management
- emergency department
- current status
- spinal cord injury
- spinal cord
- replacement therapy
- health insurance
- smoking cessation
- postoperative pain
- drug induced