Atypical Neurogenesis, Astrogliosis, and Excessive Hilar Interneuron Loss Are Associated with the Development of Post-Traumatic Epilepsy.
Erwin Kristobal Gudenschwager BassoOleksii ShandraTroy VolanthDipan C PatelColin KellyJack L BrowningXiaoran WeiElizabeth A HarrisDzenis MahmutovicAlexandra M KalossFernanda Guilhaume CorreaJeremy DeckerBiswajit MaharathiStefanie RobelHarald SontheimerPamela J VandeVordMichelle L OlsenMichelle H TheusPublished in: Cells (2023)
These findings suggest that epileptogenesis may emerge following TBI due to distinct aberrant cellular remodeling events and key molecular changes in the dentate gyrus of the hippocampus.