Intravenous thrombolysis before mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion; should we cross that bridge? A systematic review and meta-analysis of 36,123 patients.

Hazem S GhaithMohamed ElfilMohamed Diaa GabraAsmaa Ahmed NawarMohamed Sameh Abd-AlkhaleqKhaled M HamamLara Ebrahim AboelnasrEsraa Ayman ElgezeryMohamed Hosny OsmanHanaa ElsayedSarya SwedUlrick Sidney KanmounyeAhmed Negida

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2022)

For AIS-LVO, IVT + MT is associated with slightly better rates of survival, successful and complete recanalization, and favorable functional outcome as compared with MT alone. Further clinical trials are needed to corroborate such benefits of bridging IVT.

Keyphrases

acute ischemic stroke
clinical trial
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
peritoneal dialysis
pulmonary embolism
prognostic factors
high dose
randomized controlled trial
study protocol
patient reported