Activation of IL-10+ B cells: A novel immunomodulatory mechanism for therapeutic bacterial suspensions.

Alberto SalazarJane E NietoHenry Velazquez-SotoMaría Del Carmen Jiménez-Martínez

Published in: SAGE open medicine (2020)

Our findings suggest that bacterial suspension induces the activation of B cell subsets as well as the secretion of IL-6 and IL-10. Expression of TLR2 on CD19+ cells could act as an activation loop of IL-10+ B regulatory cells. The clinical implications of these findings are discussed at the end of this article.

Keyphrases

induced apoptosis
cell cycle arrest
poor prognosis
transcription factor
inflammatory response
toll like receptor
endoplasmic reticulum stress
oxidative stress