Effect of neoadjuvant chemotherapy on the immune microenvironment in non-small cell lung carcinomas as determined by multiplex immunofluorescence and image analysis approaches.
Edwin Roger Parra CuentesPamela VillalobosCarmen BehrensMei JiangApar PataerStephen G SwisherWilliam N WilliamJiexin ZhangJack LeeTina CasconeJohn V HeymachMarie-Andrée ForgetCara HaymakerChantale BernatchezNeda KalhorAnnikka WeissferdtCesar MoranJianjun ZhangAra VaporciyanDon L GibbonsBoris SepesiIgnacio I WistubaPublished in: Journal for immunotherapy of cancer (2018)
NCT-NSCLCs exhibited higher levels of PD-L1 expression and T-cell subset regulation than non-NCT-NSCLCs, suggesting that NCT activates specific immune response mechanisms in lung cancer. These results suggest the need for clinical trials and translational studies of combined chemotherapy and immunotherapy prior to surgical resection of locally advanced NSCLC.
Keyphrases
- locally advanced
- neoadjuvant chemotherapy
- rectal cancer
- immune response
- clinical trial
- squamous cell carcinoma
- radiation therapy
- phase ii study
- sentinel lymph node
- small cell lung cancer
- stem cells
- single cell
- cell therapy
- high throughput
- lymph node
- high grade
- advanced non small cell lung cancer
- randomized controlled trial
- dendritic cells
- bone marrow
- brain metastases
- phase ii
- double blind
- real time pcr
- phase iii
- study protocol