Seven New Lobane Diterpenoids from the Soft Coral Lobophytum catalai .
Jiarui ZhangHuixue MaShuangshuang JinXuehuan LiuLei LiZhaonan LiuGuo-Qiang LiPinglin LiPublished in: Marine drugs (2023)
Seven new lobane diterpenoids, namely, lobocatalens A-G ( 1 - 7 ), were isolated from the Xisha soft coral Lobophytum catalai . Their structures, including their absolute configurations, were elucidated via spectroscopic analysis, comparison with the literature data, QM-MNR, and TDDFT-ECD calculations. Among them, lobocatalen A ( 1 ) is a new lobane diterpenoid with an unusual ether linkage between C-14 and C-18. In addition, compound 7 showed moderate anti-inflammatory activity in the zebrafish models and cytotoxic activity against the K562 human cancer cell line.
Keyphrases
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