miRNA expression can classify pediatric thyroid lesions and increases the diagnostic yield of mutation testing.

Aime T FrancoEmmanuel LabourierKenny Kwabena AblordeppeyLea F SurreySogol Mostoufi-MoabAmber IsazaN Scott AdzickKen KazahayaGyanendra KumarAndrew J Bauer

Published in: Pediatric blood & cancer (2020)

These data suggest that the regulatory miRNA pathways underlying thyroid tumorigenesis are similar in adults and children. miRNA expression can identify malignant lesions with high specificity, augment the diagnostic yield of mutation testing, and improve the molecular classification of pediatric thyroid nodules.

Keyphrases

poor prognosis
machine learning
young adults
binding protein
deep learning
electronic health record
transcription factor
long non coding rna
big data
artificial intelligence
structural basis
childhood cancer