Experiences of running a stratified medicine adaptive platform trial: Challenges and lessons learned from 10 years of the FOCUS4 trial in metastatic colorectal cancer.

Louise C BrownJanet GrahamDavid FisherRichard A AdamsJenny SeligmannMatthew SeymourRichard S KaplanEmma YatesMahesh ParmarSusan D RichmanPhilip QuirkeRachel ButlerKaikeen ShiuGary MiddletonLeslie SamuelRichard H WilsonTimothy S Maughannull null

Published in: Clinical trials (London, England) (2022)

Adaptive stratified medicine platform studies are feasible in common cancers but present challenges. Our stakeholder feedback has helped to inform how these trial designs can succeed and answer multiple questions efficiently, providing resource is adequate.

Keyphrases

phase iii
study protocol
metastatic colorectal cancer
phase ii
clinical trial
high throughput
randomized controlled trial
open label
mental health
high intensity
double blind