Ineffectiveness of saxagliptin as a neuroprotective drug in 6-OHDA-lesioned rats.

Joelle de Melo TurnesTaysa Bervian BassaniLeonardo C SouzaMaria A B F Vital

Published in: The Journal of pharmacy and pharmacology (2018)

Saxagliptin treatment did not exhibit neuroprotection and it did not improve the cognitive and motor deficits in the 6-OHDA model of PD. Interestingly, when saxagliptin was administered to the sham animals, a cognitive decline was observed. Therefore, this drug should be investigated as a possible treatment for PTSD.

Keyphrases

cognitive decline
mild cognitive impairment
emergency department
combination therapy
cerebral ischemia
depressive symptoms
brain injury
drug induced
social support
replacement therapy
single molecule
atomic force microscopy