The evaluation of the overexpression of the ERG-11, MDR-1, CDR-1, and CDR-2 genes in fluconazole-resistant Candida albicans isolated from Ahvazian cancer patients with oral candidiasis.
Mehrnoush MaheronnaghshAli TeimooriParvin DehghanMahnaz FatahiniaPublished in: Journal of clinical laboratory analysis (2022)
The increased mean expressions of the CDR1 and MDR1 genes had a greater effect on fluconazole resistance among the drug-resistant strains of C. albicans in chemotherapy patients. It seemed that the accumulation of chemotherapeutic drugs in this organism stimulated some regulatory factors and increased the expression of these two genes and ultimately helped to further increase their expression and resistance to fluconazole.
Keyphrases
- candida albicans
- drug resistant
- multidrug resistant
- biofilm formation
- poor prognosis
- genome wide
- end stage renal disease
- acinetobacter baumannii
- genome wide identification
- bioinformatics analysis
- ejection fraction
- newly diagnosed
- transcription factor
- chronic kidney disease
- escherichia coli
- binding protein
- papillary thyroid
- cell proliferation
- dna methylation
- genome wide analysis
- gene expression
- squamous cell carcinoma
- squamous cell
- long non coding rna
- cystic fibrosis
- pseudomonas aeruginosa
- locally advanced