UCP1 expression in human brown adipose tissue is inversely associated with cardiometabolic risk factors.
T'ng Choong KwokLynne E RamageAlexandra KelmanKarla J SuchackiCalum D GrayLuke D BoyleScott I SempleTom MacGillivrayGillian MacNaughtDilip PatelEdwin J R van BeekRobert K SempleSonia J WakelinRoland H StimsonPublished in: European journal of endocrinology (2024)
18F-FDG uptake by BAT and UCP1 expression are preserved in young obese adults. Older subjects retain precursor cells with the capacity to form new thermogenic adipocytes. These data highlight the therapeutic potential of BAT mass expansion and activation in obesity.
Keyphrases
- adipose tissue
- insulin resistance
- poor prognosis
- risk factors
- weight loss
- metabolic syndrome
- induced apoptosis
- type diabetes
- endothelial cells
- high fat diet
- middle aged
- high fat diet induced
- binding protein
- cell cycle arrest
- physical activity
- bariatric surgery
- electronic health record
- weight gain
- long non coding rna
- big data
- pet imaging
- pet ct
- machine learning
- cell death
- oxidative stress
- obese patients
- deep learning
- artificial intelligence