Duodenal CD8+ T resident memory cell apoptosis contributes to gut barrier dysfunction and microbial translocation in early alcohol-associated liver disease in humans.

Luca MaccioniAxelle LoriotJoseph DewulfGuido BommerYves HorsmansNicolas LanthierIsabelle LeclercqBernd SchnablPeter Stärkel

Published in: Alimentary pharmacology & therapeutics (2022)

Duodenal CD8+ TRM apoptosis related to functional changes in lysosomes and lipid metabolism points to impaired gut adaptive immunity specifically in patients with AUD who developed early ALD.

Keyphrases

oxidative stress
cell proliferation
microbial community
cell death
working memory
nk cells
cell cycle arrest
quality improvement
fatty acid
alcohol use disorder
pi k akt