MicroRNA-721 regulates gluconeogenesis via KDM2A-mediated epigenetic modulation in diet-induced insulin resistance in C57BL/6J mice.

Shaheen Wasil KabeerShivam SharmaShalemraju SriramdasuKulbhushan Tikoo

Published in: Biological research (2024)

Our study unveils the role of miR-721 in regulating gluconeogenesis through KDM2A and FOXO1 under insulin resistance, pointing towards significant clinical and therapeutic implications for metabolic disorders. Moreover, the promising impact of laccaic acid highlights its potential as a valuable intervention in managing insulin resistance-associated metabolic diseases.

Keyphrases

insulin resistance
high fat diet induced
adipose tissue
high fat diet
metabolic syndrome
polycystic ovary syndrome
cell proliferation
skeletal muscle
randomized controlled trial
long non coding rna
dna methylation
gene expression
transcription factor
glycemic control
weight loss