International Changes in COVID-19 Clinical Trajectories Across 315 Hospitals and 6 Countries: Retrospective Cohort Study.
Griffin M WeberHarrison G ZhangSehi L' YiClara-Lea BonzelChuan HongPaul AvillachAlba Gutierrez-SacristanNathan P PalmerAmelia Li Min TanXuan WangWilliam YuanNils GehlenborgAnna AlloniDanilo F AmendolaAntonio BellasiRiccardo BellazziMichele BeraghiMauro BucaloLuca ChiovatoKelly ChoArianna DagliatiHossein EstiriRobert W FollettNoelia García BarrioDavid A HanauerDarren W HendersonYuk-Lam Anne HoJohn H HolmesMeghan R HutchRamakanth KavuluruKatie KirchoffJeffrey G KlannAshok K KrishnamurthyTrang T LeMolei LiuNe Hooi Will LohSara Lozano-ZahoneroYuan LuoSarah E MaidlowAdeline MakoudjouAlberto MaloviniMarcelo Roberto MartinsBertrand MoalMichele M MorrisDanielle L MoweryShawn N MurphyAntoine NeurazKee-Yuan NgiamMarina Politi OkoshiGilbert S OmennLav P PatelMiguel Pedrera JiménezRobson Aparecido PrudenteMalarkodi Jebathilagam SamayamuthuFernando J Sanz VidorretaEmily R SchriverPetra SchubertPablo Serrano BalazoteByorn W L TanSuzana Erico TanniValentina TibolloShyam VisweswaranKavishwar B WagholikarZongqi XiaDaniela Zöllernull nullIsaac S KohaneTianxi CaiAndrew Michael SouthGabriel A BratPublished in: Journal of medical Internet research (2021)
Patients hospitalized in the second wave were at significantly lower risk for severe COVID-19. This corresponded to mean laboratory values in the second wave that were more likely to be in typical physiological ranges on the seventh hospital day compared to the first wave. Our federated approach demonstrated the feasibility and power of harmonizing heterogeneous EHR data from multiple international health care systems to rapidly conduct large-scale studies to characterize how COVID-19 clinical trajectories evolve.
Keyphrases
- coronavirus disease
- sars cov
- healthcare
- end stage renal disease
- depressive symptoms
- electronic health record
- chronic kidney disease
- newly diagnosed
- ejection fraction
- respiratory syndrome coronavirus
- peritoneal dialysis
- early onset
- emergency department
- machine learning
- patient reported outcomes
- social media
- case control