Regulation of glucose uptake in lymphoma cell lines by c-MYC- and PI3K-dependent signaling pathways and impact of glycolytic pathways on cell viability.
Martina Broecker-PreussNina Becher-BovelethAndreas BockischUlrich DührsenStefan MüllerPublished in: Journal of translational medicine (2017)
c-MYC- and PI3K/mTOR-inhibitors decreased viability of the lymphoma cells and led to decreased glucose uptake, expression of glycolysis-associated genes, and glucose metabolism-regulating miRNAs. Inhibition of HK by 2-DG reduced cell numbers as a single agent and synergistically with inhibitors of other intracellular pathways. Thus, targeted inhibition of the pathways investigated here could be a strategy to suppress the glycolytic phenotype of lymphoma cells and reduce proliferation.
Keyphrases
- induced apoptosis
- signaling pathway
- diffuse large b cell lymphoma
- cell cycle arrest
- poor prognosis
- pi k akt
- cell proliferation
- cell death
- type diabetes
- blood glucose
- oxidative stress
- stem cells
- genome wide
- gene expression
- endothelial cells
- blood pressure
- high resolution
- metabolic syndrome
- adipose tissue
- bone marrow
- binding protein
- long non coding rna
- mesenchymal stem cells