German Cockroach Extract Induces Matrix Metalloproteinase-1 Expression, Leading to Tight Junction Disruption in Human Airway Epithelial Cells.
Kyung Eun LeeHye Mi JeeJung Yeon HongMi Na KimMi Seon OhYun Seon KimKyung Won KimKyu Earn KimMyung Hyun SohnPublished in: Yonsei medical journal (2019)
GCE treatment increases MMP1 expression, leading to tight junction disruption, which is transcriptionally regulated and influenced by the ERK/MAPK pathway in airway epithelial cells. These findings may contribute to developing novel therapeutic strategies for airway diseases.