Role of complementarity-determining regions 1 and 3 in pathologic amyloid formation by human immunoglobulin κ1 light chains.

Elena S KlimtchukDaniele Peterle Esther A Bullitt Lawreen H Connors John R Engen Olga Gursky

Published in: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis (2023)

The results suggest distinct amyloidogenic pathways for closely related LCs and point to the complementarity-defining regions CDR1 and CDR3, linked via the conserved internal disulfide, as key factors in amyloid formation.

Keyphrases

endothelial cells
neoadjuvant chemotherapy
transcription factor
induced pluripotent stem cells
radiation therapy
locally advanced
rectal cancer