John R Engen

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 44

Top Venues

Nature chemical biology

eLife

Nature communications

Proceedings of the National Academy of Sciences of the United States of America

Northeastern University

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Northeastern University

United States

Professor :: Chemistry and Chemical Biology

Publications

Matthew W McHenry, Peiwen Shi, Christina M Camara, Daniel T Cohen, T Justin Rettenmaier, Utsarga Adhikary, Micah A Gygi, Ka Yang, Steven P Gygi, Thomas E Wales, John R Engen, James A Wells, Loren D Walensky
Covalent inhibition of pro-apoptotic BAX. Nature chemical biology (2024)
David Yin-Wei Lin, Lauren E Kueffer, Puneet Juneja, Thomas E Wales, John R Engen, Amy H Andreotti
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. eLife 12 (2024)
Matthew W McHenry, Peiwen Shi, Christina M Camara, Daniel T Cohen, T Justin Rettenmaier, Utsarga Adhikary, Micah A Gygi, Ka Yang, Steven P Gygi, Thomas E Wales, John R Engen, James A Wells, Loren D Walensky
Covalent inhibition of pro-apoptotic BAX. Nature chemical biology 20 (8) (2024)
David Yin-Wei Lin, Lauren E Kueffer, Puneet Juneja, Thomas E Wales, John R Engen, Amy H Andreotti
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. eLife 12 (2024)
Thomas E Wales, Aleksandra Pajak, Alžběta Roeselová, Santosh Shivakumaraswamy, Steven Howell, Svend Kjær, F Ulrich Hartl, John R Engen, David Balchin
Resolving chaperone-assisted protein folding on the ribosome at the peptide level. Nature structural & molecular biology (2024)
Matthew W McHenry, Peiwen Shi, Christina M Camara, Daniel T Cohen, T Justin Rettenmaier, Utsarga Adhikary, Micah A Gygi, Ka Yang, Steven P Gygi, Thomas E Wales, John R Engen, James A Wells, Loren D Walensky
Covalent inhibition of pro-apoptotic BAX. Nature chemical biology (2024)
Matthew W McHenry, Peiwen Shi, Christina M Camara, Daniel T Cohen, T Justin Rettenmaier, Utsarga Adhikary, Micah A Gygi, Ka Yang, Steven P Gygi, Thomas E Wales, John R Engen, James A Wells, Loren D Walensky
Covalent inhibition of pro-apoptotic BAX. Nature chemical biology (2024)
Ju Rang Woo, Seung-Hyun Bae, Thomas E Wales, John R Engen, Jongsoon Lee, Hyonchol Jang, SangYoun Park
The serine phosphorylations in the IRS-1 PIR domain abrogate IRS-1 and IR interaction. Proceedings of the National Academy of Sciences of the United States of America 121 (17) (2024)
Ju Rang Woo, Seung-Hyun Bae, Thomas E Wales, John R Engen, Jongsoon Lee, Hyonchol Jang, SangYoun Park
The serine phosphorylations in the IRS-1 PIR domain abrogate IRS-1 and IR interaction. Proceedings of the National Academy of Sciences of the United States of America 121 (17) (2024)
Ju Rang Woo, Seung-Hyun Bae, Thomas E Wales, John R Engen, Jongsoon Lee, Hyonchol Jang, SangYoun Park
The serine phosphorylations in the IRS-1 PIR domain abrogate IRS-1 and IR interaction. Proceedings of the National Academy of Sciences of the United States of America 121 (17) (2024)
Ju Rang Woo, Seung-Hyun Bae, Thomas E Wales, John R Engen, Jongsoon Lee, Hyonchol Jang, SangYoun Park
The serine phosphorylations in the IRS-1 PIR domain abrogate IRS-1 and IR interaction. Proceedings of the National Academy of Sciences of the United States of America 121 (17) (2024)
Matthew W McHenry, Peiwen Shi, Christina M Camara, Daniel T Cohen, T Justin Rettenmaier, Utsarga Adhikary, Micah A Gygi, Ka Yang, Steven P Gygi, Thomas E Wales, John R Engen, James A Wells, Loren D Walensky
Covalent inhibition of pro-apoptotic BAX. Nature chemical biology (2024)
David Yin-Wei Lin, Lauren E Kueffer, Puneet Juneja, Thomas E Wales, John R Engen, Amy H Andreotti
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. eLife 12 (2024)
David Yin-Wei Lin, Lauren E Kueffer, Puneet Juneja, Thomas E Wales, John R Engen, Amy H Andreotti
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. eLife 12 (2024)
Matthew W McHenry, Peiwen Shi, Christina M Camara, Daniel T Cohen, T Justin Rettenmaier, Utsarga Adhikary, Micah A Gygi, Ka Yang, Steven P Gygi, Thomas E Wales, John R Engen, James A Wells, Loren D Walensky
Covalent inhibition of pro-apoptotic BAX. Nature chemical biology (2024)
David Yin-Wei Lin, Lauren E Kueffer, Puneet Juneja, Thomas E Wales, John R Engen, Amy H Andreotti
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. eLife 12 (2024)
Matthew W McHenry, Peiwen Shi, Christina M Camara, Daniel T Cohen, T Justin Rettenmaier, Utsarga Adhikary, Micah A Gygi, Ka Yang, Steven P Gygi, Thomas E Wales, John R Engen, James A Wells, Loren D Walensky
Covalent inhibition of pro-apoptotic BAX. Nature chemical biology 20 (8) (2024)
David Yin-Wei Lin, Lauren E Kueffer, Puneet Juneja, Thomas E Wales, John R Engen, Amy H Andreotti
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. bioRxiv : the preprint server for biology (2023)
Elena S Klimtchuk, Daniele Peterle, Esther A Bullitt, Lawreen H Connors, John R Engen, Olga Gursky
Role of complementarity-determining regions 1 and 3 in pathologic amyloid formation by human immunoglobulin κ1 light chains. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis (2023)
Pelin Ayaz, Agatha Lyczek, YiTing Paung, Victoria R Mingione, Roxana E Iacob, Parker W de Waal, John R Engen, Markus A Seeliger, Yibing Shan, David E Shaw
Structural mechanism of a drug-binding process involving a large conformational change of the protein target. Nature communications 14 (1) (2023)
Raji E Joseph, Thomas E Wales, Sandrine Jayne, Robert Graham Britton, D Bruce Fulton, John R Engen, Martin J S Dyer, Amy H Andreotti
Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia. bioRxiv : the preprint server for biology (2023)
Elena S Klimtchuk, Daniele Peterle, Esther A Bullitt, Lawreen H Connors, John R Engen, Olga Gursky
Role of Complementarity-Determining Regions 1 and 3 in Pathologic Amyloid Formation by Human Immunoglobulin κ1 Light Chains. bioRxiv : the preprint server for biology (2023)
Daniele Peterle, Thomas E Wales, John R Engen
Simple and Fast Maximally Deuterated Control (maxD) Preparation for Hydrogen-Deuterium Exchange Mass Spectrometry Experiments. Analytical chemistry 94 (28) (2022)
Ka Ying Sharon Hung, Sven Klumpe, Markus R Eisele, Suzanne Elsasser, Geng Tian, Shuangwu Sun, Jamie A Moroco, Tat Cheung Cheng, Tapan Joshi, Timo Seibel, Duco Van Dalen, Xin-Hua Feng, Ying Lu, Huib Ovaa, John R Engen, Byung-Hoon Lee, Till Rudack, Eri Sakata, Daniel Finley
Allosteric control of Ubp6 and the proteasome via a bidirectional switch. Nature communications 13 (1) (2022)
Klaus Bonazza, Roxana E Iacob, Nathan E Hudson, Jing Li, Chafen Lu, John R Engen, Timothy A Springer
Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O -glycosylated N- and C-linker. eLife 11 (2022)
Michelle S Prew, Christina M Camara, Thomas Botzanowski, Jamie A Moroco, Noah B Bloch, Hannah R Levy, Hyuk-Soo Seo, Sirano Dhe-Paganon, Gregory H Bird, Henry D Herce, Micah A Gygi, Silvia Escudero, Thomas E Wales, John R Engen, Loren D Walensky
Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nature communications 13 (1) (2022)
Noah B Bloch, Thomas E Wales, Michelle S Prew, Hannah R Levy, John R Engen, Loren D Walensky
The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core. Nature communications 12 (1) (2021)
Kelly A Manthei, Dhabaleswar Patra, Christopher J Wilson, Maria V Fawaz, Lolita Piersimoni, Jenny Capua Shenkar, Wenmin Yuan, Philip C Andrews, John R Engen, Anna A Schwendeman, Melanie D Ohi, John Joseph Grubb Tesmer
Structural analysis of lecithin:cholesterol acyltransferase bound to high density lipoprotein particles. Communications biology 3 (1) (2020)
Kyle J Korshavn, Thomas E Wales, Gregory H Bird, John R Engen, Loren D Walensky
A redox switch regulates the structure and function of anti-apoptotic BFL-1. Nature structural & molecular biology 27 (9) (2020)
Nathan J Schauer, Xiaoxi Liu, Robert S Magin, Laura M Doherty, Wai Cheung Chan, Scott B Ficarro, Wanyi Hu, Rebekka M Roberts, Roxana E Iacob, Björn Stolte, Andrew O Giacomelli, Sumner Perera, Kyle McKay, Sarah A Boswell, Ellen L Weisberg, Arghya Ray, Dharminder Chauhan, Sirano Dhe-Paganon, Ken C Anderson, James D Griffin, Jianing Li, William C Hahn, Peter Karl Sorger, John R Engen, Kimberly Stegmaier, Jarrod A Marto, Sara J Buhrlage
Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism. Scientific reports 10 (1) (2020)
Julia R Kardon, Jamie A Moroco, John R Engen, Tania A Baker
Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding. eLife 9 (2020)
Raji E Joseph, Neha Amatya, D Bruce Fulton, John R Engen, Thomas E Wales, Amy H Andreotti
Differential impact of BTK active site inhibitors on the conformational state of full-length BTK. eLife 9 (2020)
Joseph A Newman, Angeline E Gavard, Simone Lieb, Madhwesh C Ravichandran, Katja Hauer, Patrick Werni, Leonhard Geist, Jark Böttcher, John R Engen, Klaus Rumpel, Matthias Samwer, Mark Petronczki, Opher Gileadi
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers. Life science alliance 4 (1) (2020)
Ann M Cathcart, Gregory H Bird, Thomas E Wales, Henry D Herce, Edward P Harvey, Zachary J Hauseman, Catherine E Newman, Utsarga Adhikary, Michelle S Prew, Tun Oo, Susan Lee, John R Engen, Loren D Walensky
Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer. Nature chemical biology 16 (11) (2020)
John R Engen, Thomas Botzanowski, Daniele Peterle, Florian Georgescauld, Thomas E Wales
Developments in Hydrogen/Deuterium Exchange Mass Spectrometry. Analytical chemistry 93 (1) (2020)
Jianchuan Wang, Yang Su, Roxana E Iacob, John R Engen, Timothy A Springer
General structural features that regulate integrin affinity revealed by atypical αVβ8. Nature communications 10 (1) (2019)
Edward C Twomey, Zhejian Ji, Thomas E Wales, Nicholas O Bodnar, Scott B Ficarro, Jarrod A Marto, John R Engen, Tom A Rapoport
Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding. Science (New York, N.Y.) 365 (6452) (2019)
Rida Mourtada, Henry D Herce, Daniel J Yin, Jamie A Moroco, Thomas E Wales, John R Engen, Loren D Walensky
Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice. Nature biotechnology 37 (10) (2019)
Asim K Bera, Jia Lu, Thomas E Wales, Sudershan Gondi, Deepak Gurbani, Andrew Nelson, John R Engen, Kenneth D Westover
Structural basis of the atypical activation mechanism of KRASV14I. The Journal of biological chemistry 294 (38) (2019)
Glenn Robert Masson, John E Burke, Natalie G Ahn, Ganesh S Anand, Christoph Borchers, Sébastien Brier, George M Bou-Assaf, John R Engen, S Walter Englander, Johan Faber, Rachel Garlish, Patrick R Griffin, Michael L Gross, Miklos Guttman, Yoshitomo Hamuro, Albert J R Heck, Damian Houde, Roxana E Iacob, Thomas J D Jørgensen, Igor A Kaltashov, Judith P Klinman, Lars Konermann, Petr Man, Leland Mayne, Bruce D Pascal, Dana Reichmann, Mark Skehel, Joost Snijder, Timothy S Strutzenberg, Eric S Underbakke, Cornelia Wagner, Thomas E Wales, Benjamin T Walters, David D Weis, Derek J Wilson, Patrick L Wintrode, Zhongqi Zhang, Jie Zheng, David C Schriemer, Kasper Dyrberg Rand
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments. Nature methods 16 (7) (2019)
Emily J Poulin, Asim K Bera, Jia Lu, Yi-Jang Lin, Samantha Dale Strasser, Joao A Paulo, Tannie Q Huang, Carolina Morales, Wei Yan, Joshua H Cook, Jonathan A Nowak, Douglas K Brubaker, Brian A Joughin, Christian W Johnson, Rebecca A DeStefanis, Phaedra C Ghazi, Sudershan Gondi, Thomas E Wales, Roxana E Iacob, Lana Bogdanova, Jessica J Gierut, Yina Li, John R Engen, Pedro A Perez-Mancera, Benjamin S Braun, Steven P Gygi, Douglas A Lauffenburger, Kenneth D Westover, Kevin M Haigis
Tissue-Specific Oncogenic Activity of KRASA146T. Cancer discovery 9 (6) (2019)
Kexin Shen, Jamie A Moroco, Ravi K Patel, Haibin Shi, John R Engen, Heather R Dorman, Thomas E Smithgall
The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation. Science signaling 11 (553) (2018)
Nicholas O Bodnar, Kelly H Kim, Zhejian Ji, Thomas E Wales, Vladimir Svetlov, Evgeny Nudler, John R Engen, Thomas Walz, Tom A Rapoport
Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4. Nature structural & molecular biology 25 (7) (2018)
Christopher J Wilson, Madhurima Das, Shobini Jayaraman, Olga Gursky, John R Engen
Effects of Disease-Causing Mutations on the Conformation of Human Apolipoprotein A-I in Model Lipoproteins. Biochemistry 57 (30) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

John R Engen