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Genetic Survey of Psilocybe Natural Products.

Sebastian DörnerKai RoggeJanis FrickeTim SchäferJacob M WurlitzerMarkus GresslerDuyen N K PhamDavid R MankeAndrew R ChadeayneDirk Hoffmeister
Published in: Chembiochem : a European journal of chemical biology (2022)
Psilocybe magic mushrooms are best known for their main natural product, psilocybin, and its dephosphorylated congener, the psychedelic metabolite psilocin. Beyond tryptamines, the secondary metabolome of these fungi is poorly understood. The genomes of five species (P. azurescens, P. cubensis, P. cyanescens, P. mexicana, and P. serbica) were browsed to understand more profoundly common and species-specific metabolic capacities. The genomic analyses revealed a much greater and yet unexplored metabolic diversity than evident from parallel chemical analyses. P. cyanescens and P. mexicana were identified as aeruginascin producers. Lumichrome and verpacamide A were also detected as Psilocybe metabolites. The observations concerning the potential secondary metabolome of this fungal genus support pharmacological and toxicological efforts to find a rational basis for yet elusive phenomena, such as paralytic effects, attributed to consumption of some magic mushrooms.
Keyphrases
  • copy number
  • solid state
  • genetic diversity
  • cross sectional
  • single cell
  • quality improvement
  • human health
  • risk assessment
  • dna methylation