Comparison of cytotoxicity, genotoxicity and immunological inflammatory biomarker activity of several endodontic sealers against immortalized human pulp cells.

Frederico Canato MartinhoS E A CamargoA M M FernandesM S CamposR F PradoC H R CamargoM C Valera

Published in: International endodontic journal (2017)

A SV40 T-Ag-transfected cell line of human pulp-derived cells was established. The methacrylate resin-based sealer (Real Seal) exhibited the greatest cytoxicity and inflammatory potential against immortalized pulp cells compared to an epoxy resin-based sealer (AH Plus), a methacrylate-based sealer (EndoRez) and a calcium hydroxide-based sealer (Apexit).

Keyphrases

induced apoptosis
cell cycle arrest
endothelial cells
oxidative stress
endoplasmic reticulum stress
induced pluripotent stem cells
risk assessment
cell proliferation
pluripotent stem cells