PathMe: merging and exploring mechanistic pathway knowledge.
Daniel Domingo-FernándezSarah MubeenJosep Marín-LlaóCharles Tapley HoytMartin Hofmann-ApitiusPublished in: BMC bioinformatics (2019)
This work has harmonized three major pathway databases and transformed them into a unified schema in order to gain a holistic picture of pathway knowledge. We demonstrate the utility of the PathMe framework in: i) integrating pathway landscapes at the database level, ii) comparing the degree of consensus at the pathway level, and iii) exploring pathway crosstalk and investigating consensus at the molecular level.