Human Epicardial Adipose Tissue Expresses Glucose-dependent Insulinotropic Polypeptide, Glucagon and Glucagon-Like Peptide 1 Receptors as Potential Targets of Pleiotropic Therapies.
Alexis Elias MalavazosGianluca IacobellisElena DozioSara BasilicoAngelica Di VincenzoCarola DubiniLorenzo A MenicantiElena VianelloChiara MeregalliChiara RuoccoMaurizio RagniFrancesco SecchiPietro SpagnoloSerenella CastelvecchioLelio MorriconeSilvio BuscemiAntonio GiordanoJeffrey J GoldbergerMichele CarrubaSaverio CintiMassimiliano Marco Corsi RomanelliEnzo NisoliPublished in: European journal of preventive cardiology (2023)
Having reported the expression of the GLP-1 receptor previously, here, we showed that GIPR and GCGR similarly present at mRNA and protein levels in human EAT, particularly in macrophages and partially adipocytes, suggesting these G-protein-coupled receptors as pharmacological targets on the ongoing innovative drugs, which seem cardiometabolically healthy well beyond their effects on glucose and body weight..