Clinical and genetic characteristics of people with type 1 diabetes who have discrepancies in titers of anti-glutamic acid decarboxylase antibody measured by radioimmunoassay and enzyme-linked immunosorbent assay.
Satoshi TakagiJunnosuke MiuraSari HoshinaYasuko UchigataTetsuya BabazonoPublished in: Journal of diabetes investigation (2019)
The difference in the positivity for GADA-ELISA might reflect cytotoxicity toward pancreatic β-cells and preservation of endogenous insulin secretion in people with slowly progressive insulin-dependent diabetes mellitus. We also suggest that the difference in the GADA-ELISA-specific epitope depends on the human leukocyte antigen genotype.
Keyphrases
- monoclonal antibody
- induced apoptosis
- endothelial cells
- type diabetes
- cell cycle arrest
- glycemic control
- multiple sclerosis
- high throughput
- induced pluripotent stem cells
- genome wide
- pluripotent stem cells
- signaling pathway
- cell death
- oxidative stress
- skeletal muscle
- metabolic syndrome
- cell proliferation
- dna methylation
- pi k akt
- single cell