EZH2 Regulates ANXA6 Expression via H3K27me3 and Is Involved in Angiotensin II-Induced Vascular Smooth Muscle Cell Senescence.

Yuejin LiShikui GuoYingpeng ZhaoRougang LiYu LiChangtao QiuLe Xiao Kunmei Gong

Published in: Oxidative medicine and cellular longevity (2022)

EZH2 regulates the ANXA6 promoter H3K27me3 modification, inhibits ANXA6 expression, alleviates Ang II-induced VSMC senescence, and inhibits AAA progression.

Keyphrases

angiotensin ii
smooth muscle
poor prognosis
high glucose
endothelial cells
angiotensin converting enzyme
long non coding rna
vascular smooth muscle cells
dna damage
dna methylation
drug induced
gene expression
single cell
transcription factor
binding protein
long noncoding rna
mouse model