The role of statins in the differentiation and function of bone cells.
Sajad ChamaniLuca LiberaleLeila MobasheriFabrizio MontecuccoKhalid Al-RasadiTannaz JamialahmadiAmir Hossein SahebkarPublished in: European journal of clinical investigation (2021)
This review summarizes the literature exploring bone-related 'pleiotropic' effects of statins and suggests an anabolic role in the bone tissue for this drug class. Accordingly, current knowledge encourages further clinical trials to assess the therapeutic potential of statins in the treatment of bone disorders, such as arthritis and osteoporosis.
Keyphrases
- bone mineral density
- clinical trial
- cardiovascular disease
- postmenopausal women
- soft tissue
- bone loss
- bone regeneration
- systematic review
- healthcare
- induced apoptosis
- rheumatoid arthritis
- randomized controlled trial
- emergency department
- signaling pathway
- cell cycle arrest
- cell proliferation
- adverse drug
- double blind