Carbapenem Resistance among Marine Bacteria-An Emerging Threat to the Global Health Sector.
Dewa A P Rasmika DewiTorsten ThomasAna Masara Ahmad MokhtarNoreen Suliani Mat NanyanSiti Balqis ZulfigarNor Hawani SalikinPublished in: Microorganisms (2021)
The emergence of antibiotic resistance among pathogenic microorganisms is a major issue for global public health, as it results in acute or chronic infections, debilitating diseases, and mortality. Of particular concern is the rapid and common spread of carbapenem resistance in healthcare settings. Carbapenems are a class of critical antibiotics reserved for treatment against multidrug-resistant microorganisms, and resistance to this antibiotic may result in limited treatment against infections. In addition to in clinical facilities, carbapenem resistance has also been identified in aquatic niches, including marine environments. Various carbapenem-resistant genes (CRGs) have been detected in different marine settings, with the majority of the genes incorporated in mobile genetic elements, i.e., transposons or plasmids, which may contribute to efficient genetic transfer. This review highlights the potential of the marine environment as a reservoir for carbapenem resistance and provides a general overview of CRG transmission among marine microbes.
Keyphrases
- klebsiella pneumoniae
- acinetobacter baumannii
- multidrug resistant
- gram negative
- public health
- healthcare
- genome wide
- global health
- drug resistant
- escherichia coli
- risk assessment
- gene expression
- dna methylation
- drug induced
- copy number
- cystic fibrosis
- transcription factor
- health insurance
- human health
- sensitive detection
- aortic dissection