Severe primary graft dysfunction of the heart transplant is associated with increased plasma and intragraft proinflammatory cytokine expression.
Emil J HolmströmSimo O SyrjäläKishor DhaygudeRaimo TuuminenRainer KrebsAntti NykänenKarl B LemströmPublished in: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (2023)
Severe LV-PGD was associated with a poor clinical outcome. Donor and recipient plasma cytokine profile failed to predict LV-PGD, but severe LV-PGD was associated with an increase in post-reperfusion intragraft and recipient plasma proinflammatory cytokines. Identified key cytokines may be potential therapeutic targets to improve early and long-term outcomes after heart transplantation.