Expression of Par3 polarity protein correlates with poor prognosis in ovarian cancer.

Hiroe NakamuraKazunori NagasakaKei KawanaAyumi TaguchiYuriko UeharaMitsuyo YoshidaMasakazu SatoHaruka NishidaAsaha FujimotoTomoko InoueKatsuyuki AdachiTakeshi NagamatsuTakahide ArimotoKatsutoshi OdaYutaka OsugaTomoyuki Fujii

Published in: BMC cancer (2016)

Taken together, these results suggest that Par3 expression is likely involved in ovarian cancer progression, especially in peritoneal metastasis. The underlying mechanism may be that Par3 modulates IL-6 /STAT3 signaling. Here, we propose that the expression of Par3 in ovarian cancer may control disease outcome.

Keyphrases

poor prognosis
long non coding rna
binding protein
cell proliferation
amino acid
protein protein