Vitamin D status and risk of incident tuberculosis disease: A nested case-control study, systematic review, and individual-participant data meta-analysis.
Omowunmi AibanaChuan-Chin HuangSaid AboudAlberto Arnedo-PenaMercedes C BecerraJuan Bautista Bellido-BlascoRamesh BhosaleRoger CalderonSilvia ChiangCarmen ContrerasGanmaa DavaasambuuWafaie W FawziMolly F FrankeJerome T GaleaDaniel Garcia-FerrerMaria Gil-FortuñoBarbará Gomila-SardAmita GuptaNikhil GupteRabia HussainJesus Iborra-MilletNajeeha T IqbalJose Vicente Juan-CerdánAarti Avinash KinikarLeonid LeccaVidya MaveNoemi Meseguer-FerrerGrace MontepiedraFerdinand M MugusiOlumuyiwa A OwolabiJulie ParsonnetFreddy Roach-PobleteMaria Angeles Romeu-GarcíaStephen A SpectorChristopher R SudfeldMark W TenfordeToyin Omotayo TogunRosa YatacoZibiao ZhangMegan B MurrayPublished in: PLoS medicine (2019)
Our findings suggest vitamin D predicts TB disease risk in a dose-dependent manner and that the risk of TB disease is highest among HIV-positive individuals with severe vitamin D deficiency. Randomized control trials are needed to evaluate the possible role of vitamin D supplementation on reducing TB disease risk.