Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga Sphaerococcus coronopifolius.
Vangelis SmyrniotopoulosAnna Cláudia de Andrade TomazMaria de Fátima Vanderlei de SouzaEmídio Vasconcelos Leitão da CunhaRobert KissVéronique MathieuEfstathia IoannouVassilios RoussisPublished in: Marine drugs (2019)
Eight new (1-8) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga Sphaerococcus coronopifolius collected from the coastline of the Ionian Sea in Greece. The structures of the new natural products, seven of which were halogenated, and the relative configuration of their stereocenters were determined on the basis of comprehensive spectroscopic analyses, including NMR and HRMS data. Compounds 5 and 8 were found to possess in vitro antitumor activity against one murine and five human cancer cell lines with mean IC50 values 15 and 16 μM, respectively.
Keyphrases
- high resolution
- endothelial cells
- papillary thyroid
- magnetic resonance
- molecular docking
- squamous cell
- electronic health record
- pluripotent stem cells
- induced pluripotent stem cells
- big data
- lymph node metastasis
- squamous cell carcinoma
- water soluble
- mass spectrometry
- high resolution mass spectrometry
- childhood cancer
- molecular dynamics simulations
- artificial intelligence