Risk factors for depression and anxiety in painful and painless diabetic polyneuropathy: A multicentre observational cross-sectional study.
David KecAneta RajdovaJana RaputovaBlanka AdamovaIva SrotovaEva Kralickova NekvapilovaRadka Neuzilova MichalcakovaMagda HorakovaJana BelobradkovaJindrich OlsovskyPavel WeberGabriel HajasMichaela KaiserovaRadim MazanecVeronika PotockovaEdvard EhlerMartin ForgacFrank BirkleinNurcan ÜçeylerClaudia SommerJosef BednarikEva VlčkováPublished in: European journal of pain (London, England) (2021)
In large cohorts of well-defined painless and painful diabetic polyneuropathy patients and diabetic subjects without polyneuropathy, we found a high prevalence of the symptoms of depression and anxiety, mainly in painful individuals. We have confirmed neuropathic pain, its severity and cognitive processing (pain catastrophizing) as dominant risk factors for depression and anxiety. Furthermore, some demographic factors (lower age, female sex), type 2 diabetes mellitus and severity of diabetic polyneuropathy were newly identified as important contributors to emotional distress independent of pain.
Keyphrases
- neuropathic pain
- chronic pain
- type diabetes
- wound healing
- spinal cord
- spinal cord injury
- end stage renal disease
- pain management
- newly diagnosed
- clinical trial
- ejection fraction
- chronic kidney disease
- cross sectional
- metabolic syndrome
- cardiovascular disease
- study protocol
- glycemic control
- double blind
- patient reported