Fludrocortisone Plus Hydrocortisone Versus Hydrocortisone Alone as Adjunctive Therapy in Septic Shock: A Retrospective Cohort Study.

Ashley E LockG Christina GutierrezElizabeth O HandColleen A BartholRebecca L Attridge

Published in: The Annals of pharmacotherapy (2023)

FC + HC was not associated with shock reversal at greater than 72 hours or decreased in-hospital mortality. These data may be useful for determining corticosteroid regimen in patients with septic shock refractory to fluids and vasopressors. Future prospective, randomized studies are needed to further evaluate the role of FC in this patient population.

Keyphrases

septic shock
double blind
open label
case report
electronic health record
placebo controlled
big data
case control
phase ii
clinical trial
randomized controlled trial
data analysis
deep learning
artificial intelligence