Single cell transcriptomic analysis of human amnion identifies cell-specific signatures associated with membrane rupture and parturition.
Wang-Sheng WangYi-Kai LinFan ZhangWen-Jia LeiFang PanYa-Nan ZhuJiang-Wen LuChu-Yue ZhangQiong ZhouHao YingKang SunPublished in: Cell & bioscience (2022)
Apart from the conventional epithelial, fibroblast and immunocytes, human amnion cells may undergo EMT, EIT and FIT in preparation for parturition. Intense inflammation and ECM remodeling are present in the rupture zone, while enhanced apoptosis and oxidative stress in epithelial cells and zinc ion transport in fibroblasts are present in amnion regardless of the rupture zones at parturition. CCL20 derived from the major cell types of the amnion participates in labor onset.
Keyphrases
- single cell
- oxidative stress
- induced apoptosis
- endothelial cells
- cell cycle arrest
- rna seq
- cell therapy
- induced pluripotent stem cells
- endoplasmic reticulum stress
- genome wide
- cell death
- pluripotent stem cells
- ischemia reperfusion injury
- dna damage
- extracellular matrix
- stem cells
- epithelial mesenchymal transition
- gene expression
- signaling pathway
- dna methylation
- bone marrow
- oxide nanoparticles
- liquid chromatography