Successful plasmapheresis and immunoglobulin treatment for severe lipid storage myopathy: Doing the right thing for the wrong reason.

Felix KleefeldAnja von RenesseCarsten DittmayerLutz HarmsJosefine RadkeHelena RadbruchHans-Hilmar GoebelFlorence PacheUdo SchneiderMarkus SchuelkeAkinori UruhaWerner Stenzel

Published in: Neuropathology and applied neurobiology (2021)

Three consecutive skeletal muscle biopsies during a several months time-frame, showing different degrees of neutral lipid storage. This is highlighted by Oil-red-O stains (D, E, F) and electron microscopy (G, H, I). Note the impact on mitochondrial morphology with so called 'parking lots (K, L). Zooming 'in and out' into the ultrastructure, using the nanotomy platform provides interesting detailled information (http://nanotomy.org). .

Keyphrases

electron microscopy
skeletal muscle
fatty acid
oxidative stress
insulin resistance
high throughput
late onset
early onset
type diabetes
metabolic syndrome
health information
social media
drug induced
replacement therapy
smoking cessation