Increased expression of in situ IL-31RA and circulating CXCL8 and CCL2 in pemphigus herpetiformis suggests participation of the IL-31 family in the pathogenesis of the disease.
K L MoraisD MiyamotoRaquel Leao OrfaliC W MarutaC G SantiM N SottoL F F da SilvaA C C C BrancoMaria Notomi SatoV AokiPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2020)
IL-31 and IL-31RA, cytokines related to pruritus, and pro-inflammatory chemokines (CXCL8 and CCL2) seem to exert a role in the pathogenesis of PH. These findings support future studies to clarify the role of IL-31 pathway as a potential therapeutic target for patients with PH.