TERT upstream promoter methylation regulates TERT expression and acts as a therapeutic target in TERT promoter mutation-negative thyroid cancer.

Shiyong LiGuanghui HuYulu ChenYe SangQin TangRengyun Liu

Published in: Cancer cell international (2024)

This study uncovered the mechanism of promoter methylation mediated TERT activation in TERT promoter mutation-negative thyroid cancer cells and indicated TERT upstream promoter methylation as a therapeutic target for thyroid cancer.

Keyphrases

dna methylation
genome wide
transcription factor
gene expression
poor prognosis