Early Impact of Proton Beam Therapy on Electrophysiological Characteristics in a Porcine Model.
Kimitake ImamuraAmanda J DeisherJannis DickowMaryam E RettmannOmar Z YasinMark D PepinStephan HohmannHiroki KonishiAtsushi SuzukiLaura K NewmanXiaojing SunJon J KruseKenneth W MerrellMichael G HermanRobert L FooteDouglas L PackerPublished in: Circulation. Arrhythmia and electrophysiology (2023)
Irradiation of the myocardium with proton beams reduce connexin-43 expression, conduction velocity, and bipolar conducted electrogram amplitude in a large porcine model. The changes in biomarkers preceded electrophysiological changes after proton beam therapy.