miR-223-3p Prevents Necroptotic Macrophage Death by Targeting Ripk3 in a Negative Feedback Loop and Consequently Ameliorates Advanced Atherosclerosis.
Yunhui JiaLianping ChengJiaxuan YangJiaqi MaoYuhuai XieXian YangXin ZhangDingxin WangZhen ZhaoAndreas SchoberYuanyuan WeiPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Our study suggests that miR-223 to 3p expression in macrophages protects against atherosclerotic plaque rupture by limiting the formation of necrotic cores, thus providing a potential microRNA therapeutic candidate for atherosclerosis.