Ameliorative effect of Lactobacillus rhamnosus GG on acetaminophen-induced hepatotoxicity via PKC/Nrf2/PGC-1α pathway.

Hend M AhmedHanan H ShehataGamila S M El-SaeedHoda H Abou GabalSherien M El-Daly

Published in: Journal, genetic engineering & biotechnology (2022)

Our study shows that probiotic LGG supplementation exerts a prophylactic and therapeutic effect against APAP-induced hepatotoxicity through modulating the expression of PKC and the Nrf2/PGC-1α signaling pathway and eventually suppressing oxidative damage from APAP overdose.

Keyphrases

signaling pathway
drug induced
liver injury
high glucose
diabetic rats
oxidative stress
skeletal muscle
poor prognosis
epithelial mesenchymal transition
endothelial cells
protein kinase