Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins.

Jens MayerChristian HarzLaura SanchezGavin C PereiraEsther MaldenerSara R HerasLyle W OstrowJohn RavitsRanjan BatraEckart MeeseJose Luis García-PérezJohn L Goodier

Published in: Molecular neurodegeneration (2018)

Our results expand and refine recent publications on HERV-K(HML-2) and ALS. Some of our results are in conflict with recent findings and call for further specific analyses. Our profiling of HML-2 transcription in ALS opens up the possibility that HML-2 proteins other than canonical full-length Env may have to be considered when studying the role of HML-2 in ALS disease.

Keyphrases

amyotrophic lateral sclerosis
transcription factor
poor prognosis
single cell
oxidative stress