Surgical considerations in Labrune syndrome.
Andrew J KobetsDavid OrikoMari GrovesShenandoah RobinsonAlan R CohenPublished in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2020)
The pathophysiology of LS is thought to be diffuse cerebral microangiopathy and it is thought that these microhemorrhages contribute to the formation of intracranial cysts as well as diffuse calcifications. Indications for surgical intervention in LS are not well established and the heterogeneity of lesions compels them to be managed on a case-by-case basis. Based on our literature review, surgery is the standard treatment of choice for patients with progressive symptoms and growing lesions on imaging studies, with outcomes favoring less-invasive stereotactic approaches with contingencies of reservoir placement when cysts recur.
Keyphrases
- case report
- low grade
- randomized controlled trial
- minimally invasive
- high resolution
- multiple sclerosis
- coronary artery bypass
- subarachnoid hemorrhage
- single cell
- small cell lung cancer
- brain metastases
- depressive symptoms
- mass spectrometry
- combination therapy
- case control
- surgical site infection
- cerebral ischemia
- brain injury
- high grade
- metabolic syndrome
- optic nerve
- blood brain barrier