Population pharmacokinetics of flucloxacillin as intermittent bolus infusion in patients with Staphylococcus aureus bloodstream infection.

Laura HermannVerena SchöningSarah DrägerKatharina M RentschStephan MoserNicolas GürtlerParham SendiMichael Osthoff Felix Hammann

Published in: The Journal of antimicrobial chemotherapy (2024)

By utilizing data from clinical routine, we were able to create a predictive PopPK model of flucloxacillin and identify influential covariates. The web-based app is currently being validated in a clinical trial.

Keyphrases

staphylococcus aureus
clinical trial
electronic health record
low dose
high intensity
big data
phase ii
gram negative
biofilm formation
randomized controlled trial
methicillin resistant staphylococcus aureus
escherichia coli
multidrug resistant
deep learning